Ongoing studies

BETTER STUDIES

The current recommendation for the treatment of hypoglycemia is to consume 15 to 20g of carbohydrates, wait 15 minutes before measuring the blood sugar and repeat the treatment if hypoglycemia persists. However, this recommendation is based on studies conducted some 30 years ago and with different insulins from the insulin analogs currently used. In addition, it has been reported that a large majority of patients consume more than 20g of carbohydrates to treat hypoglycemia. Recent data also suggests that a treatment with 15g of carbohydrates does not treat a significant proportion of hypoglycemia. The objective of this study is to determine whether the current recommendation for the treatment of hypoglycemia should be updated.

INCLUSION CRITERIA

To participate, you must: 1) be over 18 years of age; 2) have had type 1 diabetes for more than one year; 3) use the insulin pump or multiple insulin injections.

INVOLVEMENT

You will have to come to the IRCM in Montreal 5 times. The first visit (3 hours) aims to confirm your eligibility. The other four visits are aimed at testing two treatments to correct induced hypoglycemia at two different glycemic thresholds:

  • A 16g carbohydrate treatment when blood glucose is below 3.0 mmol / L
  • A 32g carbohydrate treatment when blood glucose is below 3.0 mmol / L
  • A 16g carbohydrate treatment when the blood glucose is between 3.0 and 3.5 mmol / L
  • A 32g carbohydrate treatment when the blood glucose is between 3.0 and 3.5 mmol / L
Financial compensation will be given for each completed visit.

INFORMATIONS

OTHER STUDIES

The team of Dr. Anne-Sophie Brazeau from the School of Human Nutrition at McGill is inviting you to participate in a food literacy study. The main objective of study is to understand the motivations and barriers of food choices of young adults living with and without type 1 diabetes.

INCLUSION CRITERIA

  • Be an adult aged 18-29 years old
  • Be living with or without type 1 diabetes
  • Be able to communicate in English or French

INVOLVEMENT

Complete a questionnaire (+/- 25 minutes)

Complete the survey online.

Have the chance to win an iPad mini!

INFORMATIONS

The Clinic of the Institut de recherche cliniques de Montréal (IRCM) is seeking participants for a research project on the effectiveness of basal insulin dose reduction in reducing hypoglycemia during continuous exercise and interval exercise in adolescents and adults with type 1 diabetes using the insulin pump. The objective of this study is to test strategies to reduce the risk of hypoglycemia during and after exercise.

Financial compensation will be given. The project is being carried out under the supervision of Dr. Laurent Legault (Montreal Children’s Hospital), Dr. Rémi Rabasa-Lhoret (IRCM) and Dr. Melanie Henderson (Centre hospitalier universitaire Sainte-Justine).

INVOLVEMENT

This study involves five visits (Montreal) within a period of five months. The first 3-hour visit aims to determine your eligibility. Subsequently, four visits are planned to test two different strategies to reduce hypoglycemia during exercise (continuous or interval): reducing the basal insulin dose by 80% 90 minutes before the start of exercise, and reducing the basal insulin dose by 40% 90 minutes before the start of exercise.

Both strategies will involve two 3.5-hour visits to the IRCM. The effectiveness of two post-exercise strategies to reduce the risk of post-exercise hypoglycemia will be evaluated by reducing the basal insulin dose and reducing the dinner bolus, and snacking after exercise, regular bolus at dinner and afternoon snack.

INCLUSION CRITERIA

  • Have been diagnosed with type 1 diabetes for more than two years
  • Be over 14 years of age
  • Use the insulin pump for at least 3 months

INFORMATIONS

The IRCM clinic is seeking volunteers to participate in the research project evaluating the efficacy of the external artificial pancreas in preventing hypoglycemia and maximizing time of glucose levels spent in target range in adults with type 1 diabetes.

INCLUSION CRITERIA

  • Clinical diagnosis of type 1 diabetes for at least 1 year
  • Be over 18 years of age
  • Using an insulin pump  for at least three months

INVOLVEMENT

This study involves at least two clinic visits lasting two to four hours (Montreal). A first visit of about four hours takes place at the research centre to determine the eligibility of the participant. Thereafter, at least one additional visit will take place to explain how to use the artificial pancreas. 

  • One admission visit
  • A 12-day period with the artificial pancreas and a CGM (continuous glucose monitor). 
  • A 12-day period with the users’ current pump and CGM.
  • Three or four telephone calls during the 12-day periods and staff available on-call for 24-hour.

The admission visit involves a three- to four-hour period to ensure that participants are well trained on the artificial pancreas system.

INFORMATIONS

The IRCM Clinic is seeking volunteers for a research project on the study of people with type 1 diabetes with cardiovascular disease. The objective of the study is to measure the impact of spontaneous hypoglycemia on the heart.

Financial compensation will be given. The project is being carried out under the supervision of Dr. Rémi Rabasa-Lhoret and Dr. Hélène Mansaray.

INVOLVEMENT

This study involves a visit to the IRCM clinic (Montreal) for approximately two hours. We will ask you to wear a Holter (device which measures your heart’s rhythm) and a Freestyle Libre continuous glucose monitor for 48 hours.

INCLUSION CRITERIA

  • Clinical diagnosis of type 1 diabetes for at least 6 months
  • Be over 18 years of age
  • Have either a history of cardiovascular disease or more than 30 years of diabetes

INFORMATIONS

This research project concerns compares the effect of a very-low-carbohydrate-high-fat diet (ketogenic diet) to a control diet (recommended by Diabetes Canada).
The objectives of this project are to evaluate how to adjust insulin and what are the short-term health effects in patients with type 1 diabetes who adopt the ketogenic diet.

INVOLVEMENT

The study includes 5 visits at the IRCM (Montreal) spread over 6 months and is divided into 4 phases:

  • Visit 1: Aims to determine eligibility to participate in the study. It includes different tests to assess your health. Duration of the visit ≈4h.
    • Start of phase 1: Adjust insulin doses (1 to 3 weeks).
  • Visit 2: Includes teachings to start and follow one of the two diets (ketogenic or control, random order). Duration of the visit ≈1h30.
    • Start of phase 2: Adoption of the 1st diet for 6 weeks.
  • Visit 3: Includes the various tests to assess your health at the end of the diet. Duration of the visit ≈2h30.
    • Start of phase 3: Return to your regular habits for 4 weeks.
  • Visit 4: Includes teachings to begin and follow the second diet (ketogenic or control). Duration of the visit ≈1h30.
    • Start of phase 4: Adoption of the 2nd diet for 6 weeks.
  • Visit 5: Includes the various tests to assess your health at the end of the diet. Duration of the visit ≈2h30.

This study also requires 3 visits at the CHUM to have an MRI (Magnetic Resonance Imaging) examination of the liver. The duration of each of these visits is approximately 45 minutes.

The results of this research project will provide healthcare professionals with important information to guide and support patients who choose to adhere to the ketogenic diet.

This project is under the direction of Dr. Rémi Rabasa-Lhoret, researcher and physician, and Dr. Anne-Sophie Brazeau, researcher and nutritionist.

INCLUSION CRITERIA

•    Be 18 years old or older;
•    Have been diagnosed with type 1 diabetes for at least 1 year;
•    Use at least 4 insulin injections per day or an insulin pump; 
•    Own a smartphone or tablet.

INFORMATIONS

The IRCM clinic is seeking volunteers for a research project on the comparison of ultra-fast acting insulin (FIASP) and fast acting insulin (Novorapid) on blood sugar management during exercise following a meal. 

Financial compensation will be given. The project is being carried out under the supervision of Dr. Rémi Rabasa-Lhoret.

INCLUSION CRITERIA

  • Clinical diagnosis of type 1 diabetes for at least 1 year
  • Be over 18 years of age
  • Using multiple daily injections as a treatment modality (basal/bolus)

INVOLVEMENT

This study involves a total of five visits (Montreal), including one admission visit and four intervention visits. The admission visit lasts about two hours and will determine your eligibility to participate in the study. 

Intervention visits last about five hours. Breakfast will be served in the morning and two different strategies will be tested: one-hour cycling one hour after the meal, and two hours after the meal.

INFORMATIONS